Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography. Issue 92 (21st September 2015)

• Record Type: Journal Article
• Authors: Wang, Yuchuan; Tsang, Cheuk-Nam; Xu, Feng; Kong, Pak-Wing; Hu, Ligang; Wang, Junwen; Chu, Ivan Keung; Li, Hongyan; Sun, Hongzhe
• Is Part Of: Chemical communications. Volume 51:Issue 92(2015)
• Page Start: 16479
• Page End: 16482
• Publication Date: 2015-09-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc04958j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Bi-binding motifs were mined in H. pylori by Bi-IMAC and the putative Bi-targets were analyzed by structural and bioinformatics approaches. Abstract : Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi 3+ exhibits high selectivity towards peptide enriched by cysteines and histidines with dominated motif patterns of CX n C, CX n H and HX n H. Structural rationalization and functional categorization on the identified Bi-binding peptides and proteins provide an insight into the inhibitory action of bismuth drugs.