Evaluation of risk‐factor‐based screening for thyroid peroxidase antibody positivity in pregnancy. (11th May 2015)

• Record Type: Journal Article
• Authors: Aghajanian, Paola; Spencer, Carole A.; Wilson, Melissa L.; Lee, Richard H.; Goodwin, Thomas M.; Mestman, Jorge H.
• Is Part Of: Clinical endocrinology. Volume 84:Number 3(2016)
• Page Start: 417
• Page End: 422
• Publication Date: 2015-05-11
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.12782
• Languages: English
• ISSNs: 0300-0664

Abstract

Summary: Objective: To determine whether risk‐factor‐based screening for thyroid dysfunction in pregnancy performs well for detecting thyroid peroxidase antibodies (TPOAb), a marker for autoimmune thyroid disease. Study Design: We prospectively evaluated pregnant women for thyroid dysfunction using The Endocrine Society's eleven screening questions. Serum was analysed for TPOAb. Result: We enrolled 546 women. TPOAb positivity was higher in women with a personal (odds ratio (OR) = 8·0; 95% confidence interval (CI) = 1·7–37·4; P = 0·02) or family history of thyroid disease (OR = 2·7; 95% CI = 1·3–5·7; P = 0·02). There was no association between the number of positive responses and TPOAb positivity ( P = 0·41). Risk‐factor‐based screening missed 18 women (33%) with TPOAb. Conclusion: One‐third of women with TPOAb were missed by the case‐finding method. A personal or family history of thyroid disease was most strongly associated with TPOAb positivity.