Direct gem-difluoromethylenation of sp3-hybridized carbon center through copper-mediated radical/radical cross-coupling for the construction of a CH2–CF2 linkage. Issue 87 (27th August 2015)

• Record Type: Journal Article
• Authors: Jiang, Haizhen; Xu, Minjun; Lu, Wenjun; Tian, Wenfeng; Wan, Wen; Chen, Yunrong; Deng, Hongmei; Wu, Shaoxiong; Hao, Jian
• Is Part Of: Chemical communications. Volume 51:Issue 87(2015)
• Page Start: 15756
• Page End: 15759
• Publication Date: 2015-08-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc05677b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient gem -difluoromethylenation of benzyl bromides through copper-mediated direct radical/radical C–C cross-coupling has been developed for the construction of CH2 –CF2 linkage. Abstract : Efficient direct gem -difluoromethylenation of an sp 3 -hybridized carbon center in benzyl bromides using benzo-1, 3-azolic (oxa-, thia- or aza-) difluoromethyl bromides for construction of a CH2 –CF2 linkage has been developed through radical/radical C–C cross-coupling via two separate single electron transfer processes (SET) under the promotion of different copper sources.