Asthma and asthma medication use among 4-year-old offspring of subfertile couples – association with IVF?. Issue 5 (November 2015)

• Record Type: Journal Article
• Authors: Kuiper, Derk B.; Seggers, Jorien; Schendelaar, Pamela; Haadsma, Maaike L.; Roseboom, Tessa J.; Heineman, Maas J.; Hadders-Algra, Mijna
• Is Part Of: Reproductive biomedicine online. Volume 31:Issue 5(2015)
• Page Start: 711
• Page End: 714
• Publication Date: 2015-11
• Subjects: assisted reproductive techniques -- asthma medication -- asthma -- in-vitro fertilization -- time to pregnancy; Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2015.08.002
• Languages: English
• ISSNs: 1472-6483

Abstract

Abstract: This study evaluated the prevalence of asthma and asthma medication use in 213 4-year-old singletons followed from birth onwards, including three groups of children born following: (i) controlled ovarian hyperstimulation IVF/intracytoplasmic sperm injection (ICSI); (ii) modified natural cycle IVF/ICSI; and (iii) natural conception in subfertile couples. The rate of asthma medication was higher in the ovarian hyperstimulation-IVF/ICSI than in the subfertile group (adjusted odds ratios [aOR]: 1.96 [1.00–3.84]). Time to pregnancy, a proxy for the severity of subfertility, was not associated with asthma and asthma medication. In conclusion, controlled ovarian hyperstimulation-IVF/ICSI is associated with the use of asthma medication in 4-year-old offspring of subfertile couples.