Efficient conversion of acids and esters to amides and transamidation of primary amides using OSU-6. Issue 48 (2nd December 2015)

• Record Type: Journal Article
• Authors: Nammalwar, Baskar; Muddala, Nagendra Prasad; Watts, Field M.; Bunce, Richard A.
• Is Part Of: Tetrahedron. Volume 71:Issue 48(2015)
• Page Start: 9101
• Page End: 9111
• Publication Date: 2015-12-02
• Subjects: Carboxamide synthesis -- Transamidation -- Mesoporous silica -- Acid catalysis -- Recyclable catalyst; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2015.10.016
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: OSU-6, an MCM-41 type hexagonal mesoporous silica with strong Bronsted acid properties, has been used to promote the high-yield conversion of carboxylic acids and esters to carboxamides as well as transamidations of primary amides in a one-pot solventless approach. A metal-free heterogeneous catalyst that promotes all of these processes has not been previously reported. OSU-6 enables these transformations to proceed in shorter times and at lower temperatures for a broad range of substrates. An added benefit is that the catalyst can be recycled and reused multiple times without significant loss of activity. Graphical abstract: