Palladium-catalyzed borylation of m-dibromobenzene derivative and its applications in one-pot tandem Suzuki–Miyaura arenes synthesis. Issue 47 (25th November 2015)

• Record Type: Journal Article
• Authors: Xie, Dahai; Li, Rong; Zhang, Dengqing; Hu, Jiena; Xiao, Duoduo; Li, Xianying; Xiang, Yunjie; Jin, Wusong
• Is Part Of: Tetrahedron. Volume 71:Issue 47(2015)
• Page Start: 8871
• Page End: 8875
• Publication Date: 2015-11-25
• Subjects: Borylation -- Suzuki–Miyaura -- Cross-coupling -- One-pot -- Arenes; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2015.10.011
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: One-step synthesis of several α, ω pinacol boronates starting from m -dibromobenzene derivative and bis(pinacolato)diboron through Miyaura reaction has been reported. The present approach provided low to moderate yields of monomer boronates, and trace to low yields of dimmer, trimer and tetramer boronates. Furthermore, the resulted boronates can be followed by Suzuki–Miyaura cross-coupling without purification, which enhances the practical usefulness of this method. Graphical abstract: One-step synthesis of monomer, dimmer, trimer, and tetramer boronates through Miyaura reaction in a moderate yields has been reported. Furthermore, the boronates can be followed by Suzuki–Miyaura cross-coupling without purification.