A practical, chemoselective approach to O-methylation of carboxylic acids with dimethyl malonate. Issue 48 (2nd December 2015)
- Record Type:
- Journal Article
- Title:
- A practical, chemoselective approach to O-methylation of carboxylic acids with dimethyl malonate. Issue 48 (2nd December 2015)
- Main Title:
- A practical, chemoselective approach to O-methylation of carboxylic acids with dimethyl malonate
- Authors:
- Mao, Jincheng
Liu, Defu
Li, Yongming
Zhao, Jinzhou
Rong, Guangwei
Yan, Hong
Zhang, Guoqi - Abstract:
- Abstract: A practical and chemoselective method is described for the O-methylation of carboxylic acids. Dimethyl malonate, a low toxic and commercially available compound was found to be an effective methylating reagent for a variety of carboxylic acids affording methyl ester products in good to high yields and with excellent chemoselectivity, without the use of strong bases as additives. A mechanism involving the utilization of potassium bromide is tentatively proposed. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 71:Issue 48(2015)
- Journal:
- Tetrahedron
- Issue:
- Volume 71:Issue 48(2015)
- Issue Display:
- Volume 71, Issue 48 (2015)
- Year:
- 2015
- Volume:
- 71
- Issue:
- 48
- Issue Sort Value:
- 2015-0071-0048-0000
- Page Start:
- 9067
- Page End:
- 9072
- Publication Date:
- 2015-12-02
- Subjects:
- O-Methylation -- Carboxylic acids -- Dimethyl malonate -- Chemoselective -- Potassium bromide
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2015.10.024 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 554.xml