"Cleaning" the surface of hydroxyapatite nanorods by a reaction-dissolution approach. Issue 39 (3rd September 2015)

• Record Type: Journal Article
• Authors: Cao, Binrui; Yang, Mingying; Wang, Lin; Xu, Hong; Zhu, Ye; Mao, Chuanbin
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 39(2015)
• Page Start: 7667
• Page End: 7672
• Publication Date: 2015-09-03
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb01509j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A new facile reaction-dissolution approach to surfactant-free hydroxyapatite nanorods for the removal of cytotoxic molecules from the nanoparticle surface and the subsequent construction of a biomimetic osteogenesis-inducing bioscaffold. Abstract : Synthetic nanoparticles are always terminated with coating molecules, which are often cytotoxic and not desired in biomedicine. Here we propose a novel reaction-dissolution approach to remove the cytotoxic coating molecules. A two-component solution is added to the nanoparticle solution; one component reacts with the coating molecules to form a salt whereas another is a solvent for dissolving and thus removing the salt. As a proof of concept, this work uses a NaOH–ethanol solution to remove the cytotoxic linoleic acid molecules coated on the hydroxyapatite nanorods (HAP-NRs). The removal of the coating molecules not only significantly improves the biocompatibility of HAP-NRs but also enables their oriented attachment into tightly-bound superstructures, which mimic the organized HAP crystals in bone and enamel and can promote the osteogenic differentiation of mesenchymal stem cells. Our reaction-dissolution approach can be extended to the surface "cleaning" of other nanomaterials.