Selective reduction of nitro-compounds to primary amines by nickel-catalyzed hydrosilylative reduction. Issue 103 (6th October 2015) - Sun, Shuai
Abstract : The tolerances of many functional groups, e.g . aryl-chloride, aryl-bromide, alkene, alkynyl, ester, ether, oxhydryl, carboxylic acid, cyano group, nitrine, carbonyl, acyl, thioether and some heterocycles, were studied with unprecedentedly high chemoselectivity. Abstract : Ni(acac)2 and PMHS were found to be an excellent catalytic system for the chemoselective transfer hydrogenation of nitro-compounds to primary amines. Under mild conditions a series of nitro-compounds containing a variety of sensitive functional groups including aldehydes, esters, cyano, and nitrine were reduced to their corresponding amines in good to excellent yields with no byproduct.