This is an interim version of our Electronic Legal Deposit Catalogue-eJournals and eBooks while we continue to recover from a cyber-attack.
A novel one-pot multi-component synthesis of 3, 3'-disubstituted oxindole and spirooxindole scaffolds via Sn-catalyzed C(sp3)–H functionalization of azaarenes by sequential Knoevenagel–Michael-cyclization reaction. Issue 99 (23rd September 2015)
Record Type:
Journal Article
Title:
A novel one-pot multi-component synthesis of 3, 3'-disubstituted oxindole and spirooxindole scaffolds via Sn-catalyzed C(sp3)–H functionalization of azaarenes by sequential Knoevenagel–Michael-cyclization reaction. Issue 99 (23rd September 2015)
Main Title:
A novel one-pot multi-component synthesis of 3, 3'-disubstituted oxindole and spirooxindole scaffolds via Sn-catalyzed C(sp3)–H functionalization of azaarenes by sequential Knoevenagel–Michael-cyclization reaction
Abstract : Sn-catalyzed C(sp 3 )–H bond functionalization of 2-methyl azaarenes/2-(azaaryl)methanes has been achieved for the first time in a one-pot reaction with isatin and active methylene compounds. Abstract : Sn-catalyzed C(sp 3 )–H bond functionalization of 2-methyl azaarenes/2-(azaaryl)methanes has been achieved for the first time in a one-pot multi-component reaction with isatin and active methylene compounds via tandem sequential Knoevenagel–Michael-intramolecular C–N cyclization. This strategy provides new cost-effective access to potent and biologically/medicinally important spirooxindoles/3, 3′-disubstituted 2-oxindoles in good to excellent yields.