An anti‐interferon activity shared by paramyxovirus C proteins: Inhibition of Toll‐like receptor 7/9‐dependent alpha interferon induction. Issue 1 (20th November 2013)

• Record Type: Journal Article
• Authors: Yamaguchi, Mayu; Kitagawa, Yoshinori; Zhou, Min; Itoh, Masae; Gotoh, Bin
• Is Part Of: FEBS letters. Volume 588:Issue 1(2014)
• Page Start: 28
• Page End: 34
• Publication Date: 2013-11-20
• Subjects: IFN -- interferon -- PIVs -- parainfluenza viruses -- MeV -- measles virus -- NiV -- Nipah virus -- ORF -- open reading frame -- SeV -- Sendai virus -- ISGs -- IFN-stimulated genes -- ds -- double stranded -- PKR -- protein kinase R -- PAMPs -- pathogen-associated molecular patterns -- IRF -- interferon regulatory factor -- RIG-I -- retinoic acid-inducible gene-I -- MDA5 -- melanoma differentiation-associated gene 5 -- RLRs -- RIG-I-like receptors -- TLR -- Toll-like receptor -- TRAF6 -- tumor necrosis factor receptor-associated 6 -- pDCs -- plasmacytoid dendritic cells -- IKKα -- IκB kinase alpha -- IRAK1 -- interleukin-1 receptor-associated kinase 1 -- IPS-1 -- IFN-β promoter stimulator-1 -- TRIF -- TIR-domain-containing adapter-inducing interferon-β -- N -- nucleocapsid protein -- P -- phosphoprotein -- bPIV3 -- bovine PIV type 3 -- MyD88 -- myeloid differentiation factor 88 -- ELISA -- enzyme-linked immunosorbent assay -- mAb -- monoclonal antibody -- SDS -- sodium dodecyl sulfate -- pAb -- polyclonal antibody -- Paramyxovirus -- C protein -- TLR7 -- Interferon-α -- pDC; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.11.015
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Paramyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. To identify its unknown anti‐IFN activity, we examined the effect of Sendai virus C protein on activation of the IFN‐α promoter via various signaling pathways. This study uncovers a novel ability of C protein to block Toll‐like receptor (TLR) 7‐ and TLR9‐dependent IFN‐α induction, which is specific to plasmacytoid dendritic cells. C protein interacts with a serine/threonine kinase IKKα and inhibits phosphorylation of IRF7. This anti‐IFN activity of C protein is shared across genera of the Paramyxovirinae, and thus appears to play an important role in paramyxovirus immune evasion. Abstract : We identified a novel anti‐interferon activity of paramyxovirus C protein. C protein inhibits TLR7/9‐dependent alpha interferon induction. C protein binds to IKKα and inhibits phosphorylation of IRF7. The novel anti‐interferon activity of C protein is shared across genera.