Tropism distribution among antiretroviral-naive HIV-2-infected patients. (23rd October 2015)

• Record Type: Journal Article
• Authors: Visseaux, Benoit; Charpentier, Charlotte; Ozanne, Alexandra; Nizard, Alexis; Drumard, Suzon; Fagard, Catherine; Glohi, David; Damond, Florence; Brun-Vézinet, Françoise; Matheron, Sophie; Descamps, Diane
• Is Part Of: AIDS. Volume 29:Number 16(2015)
• Publication Date: 2015-10-23
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000000825
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : The aim of this study was to describe HIV-2 R5/X4-tropism distribution in antiretroviral-naive HIV-2-infected patients. Population sequencing of the gp105 region was performed on peripheral blood mononuclear cells issued from 151 antiretroviral-naive patients. Tropism was successfully determined in 46 of 151 samples (30%) with six of 46 (13%) X4-tropic viruses. X4-tropism was associated with lower CD4 + cell count (337 vs. 551/mm 3 ; P = 0.032) but not with plasma viral load. Thus, X4-tropism prevalence in HIV-2 antiretroviral-naive patients is similar to that observed in HIV-1.