Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa. (1st November 2015)

• Record Type: Journal Article
• Authors: Budgell, Eric P.; Maskew, Mhairi; Long, Lawrence; Sanne, Ian; Fox, Matthew P.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 70:Number 3(2015)
• Publication Date: 2015-11-01
• Subjects: antiretroviral therapy -- mortality -- lost to follow-up -- survival -- retention; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000755
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: In resource-limited settings, early mortality on antiretroviral therapy (ART) is approximately 10%; yet, it is unclear how much of that mortality occurs in care or after lost to follow-up. We assessed mortality rates and predictors of death among 12, 222 nonpregnant ART-naive adults initiating first-line ART between April 2004 and May 2012 in South Africa, stratified by person-years in care and lost. We found 14.6% of patients died and being lost accounted for a minority of deaths across multiple definitions of loss (population attributable-risk percent ranged from 10.4% to 42.5%). Although mortality rates in patients lost were much higher than in care, most ART-related mortality occurred on treatment. Abstract : Supplemental Digital Content is Available in the Text.