Comorbidity as predictor poor prognosis for patients with advanced head and neck cancer treated with major surgery. Issue 3 (4th June 2015)

• Record Type: Journal Article
• Authors: Omura, Go; Ando, Mizuo; Saito, Yuki; Kobayashi, Kenya; Yamasoba, Tatsuya; Asakage, Takahiro
• Is Part Of: Head & neck. Volume 38:Issue 3(2016)
• Page Start: 364
• Page End: 369
• Publication Date: 2015-06-04
• Subjects: comorbidity -- advanced head and neck cancer -- Adult Comorbidity Index‐27 (ACE‐27) -- prognostic factor -- radical surgery; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23897
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The impact of comorbidities on patients with advanced head and neck cancer treated with major surgery has not been reported before. Methods: We retrospectively reviewed clinical charts between 2004 and 2011 at our institution and identified 185 patients with clinical stage III to IV head and neck cancer treated with major surgery. Comorbidities were scored using the Adult Comorbidity Evaluation‐27 (ACE‐27) index manual. Results: Patients with ACE‐27 ≥2 had significantly worse overall survival (OS) and disease‐specific survival (DSS) than those with ACE‐27 ≤1 ( p < .0001 and p = .0047, respectively). Multivariate analyses revealed that ACE‐27 ≥2 and extracapsular spread (ECS) were independently significant adverse prognostic factors for OS and DSS. In addition, patients with ACE‐27 ≥2 had a higher incidence of distant metastases ( p = .0057). Conclusion: The current study suggests that comorbidities may predict poor prognosis and development of distant metastases for patients with advanced head and neck cancer treated with major surgery. © 2015 Wiley Periodicals, Inc. Head Neck 38: 364–369, 2016