Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic. Issue 83 (4th September 2015)
- Record Type:
- Journal Article
- Title:
- Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic. Issue 83 (4th September 2015)
- Main Title:
- Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic
- Authors:
- Maruani, Antoine
Savoie, Huguette
Bryden, Francesca
Caddick, Stephen
Boyle, Ross
Chudasama, Vijay - Abstract:
- Abstract : A next-generation antibody-based photodynamic therapeutic is assembled and shown to be potent and selective in vitro . Abstract : Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free "click" assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.
- Is Part Of:
- Chemical communications. Volume 51:Issue 83(2015)
- Journal:
- Chemical communications
- Issue:
- Volume 51:Issue 83(2015)
- Issue Display:
- Volume 51, Issue 83 (2015)
- Year:
- 2015
- Volume:
- 51
- Issue:
- 83
- Issue Sort Value:
- 2015-0051-0083-0000
- Page Start:
- 15304
- Page End:
- 15307
- Publication Date:
- 2015-09-04
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5cc06985h ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 347.xml