Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents. Issue 85 (9th September 2015)

• Record Type: Journal Article
• Authors: Venkatramaiah, N.; Pereira, Patrícia M. R.; Almeida Paz, Filipe A.; Ribeiro, Carlos A. F.; Fernandes, Rosa; Tomé, João P. C.
• Is Part Of: Chemical communications. Volume 51:Issue 85(2015)
• Page Start: 15550
• Page End: 15553
• Publication Date: 2015-09-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc06561e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Phthalocyanines with phosphonic acid groups have a PDT effect on UM-UC-3 bladder cancer cells and inhibit urokinase-type plasminogen activator and matrix metalloproteinase-9. Abstract : Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce phototoxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).