Metal-free synthesis of N-fused heterocyclic iodides via C–H functionalization mediated by tert-butylhydroperoxide. Issue 82 (1st September 2015)

• Record Type: Journal Article
• Authors: Sharma, Krishna K.; Patel, Dhananjay I.; Jain, Rahul
• Is Part Of: Chemical communications. Volume 51:Issue 82(2015)
• Page Start: 15129
• Page End: 15132
• Publication Date: 2015-09-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc04013b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Direct, regioselective and metal-free synthesis of fused N-heterocyclic iodides is reported. Abstract : Direct, regioselective and metal-free synthesis of fused N-heterocyclic iodides is reported. This regioselective C–H functionalization is mediated by tert -butylhydroperoxide (TBHP), via dual activation of molecular iodine and a heterocyclic substrate, resulting in the in situ generation of electrophilic iodine species (I + ), and free radical(s) t BuO˙ or t BuOO˙, driving the iodination reaction.