A molecular fluorescent dye for specific staining and imaging of RNA in live cells: a novel ligand integration from classical thiazole orange and styryl compounds. Issue 83 (2nd September 2015)

• Record Type: Journal Article
• Authors: Lu, Yu-Jing; Deng, Qiang; Hu, Dong-Ping; Wang, Zheng-Ya; Huang, Bao-Hua; Du, Zhi-Yun; Fang, Yan-Xiong; Wong, Wing-Leung; Zhang, Kun; Chow, Cheuk-Fai
• Is Part Of: Chemical communications. Volume 51:Issue 83(2015)
• Page Start: 15241
• Page End: 15244
• Publication Date: 2015-09-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc05551b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new RNA-selective fluorescent dye shows excellent nucleolus RNA staining and imaging performance in live cells. Abstract : A new RNA-selective fluorescent dye integrated with a thiazole orange and a p -(methylthio)styryl moiety shows better nucleolus RNA staining and imaging performance in live cells than the commercial stains. It also exhibits excellent photostability, cell tolerance, and counterstain compatibility with 4′, 6-diamidino-2-phenylindole for specific RNA–DNA colocalization in bioassays.