Amyloid in dementia associated with familial FTLD: not an innocent bystander. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Naasan, Georges; Rabinovici, Gil D.; Ghosh, Pia; Elofson, Jonathan D.; Miller, Bruce L.; Coppola, Giovanni; Karydas, Anna; Fong, Jamie; Perry, David; Lee, Suzee E.; Yokoyama, Jennifer S.; Seeley, William W.; Kramer, Joel H.; Weiner, Michael W.; Schuff, Norbert; Jagust, William J.; Grinberg, Lea T.; Pribadi, Mochtar; Yang, Zhongan; Sears, Renee; Klein, Eric; Wojta, Kevin; Rosen, Howard J.
• Is Part Of: Neurocase. Volume 22:Issue 1(2016)
• Page Start: 76
• Page End: 83
• Publication Date: 2016-01-02
• Subjects: frontotemporal dementia -- Alzheimer's disease -- amyloid -- MRI -- FDG-PET; Neurology -- Periodicals; Neuropsychology -- Case Report; Mental Disorders -- Case Report; Nervous System Diseases -- Case Report; 616.8
• DOI: 10.1080/13554794.2015.1046458
• Languages: English
• ISSNs: 1355-4794

Abstract

Abstract : Patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case–control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer's disease-like pattern of neurodegeneration.