Eccrine porocarcinoma with extensive cutaneous metastases. (13th November 2015)

• Record Type: Journal Article
• Authors: Montes‐Torres, Andrea; Pérez‐Plaza, Alejandra; Llamas‐Velasco, Mar; Gordillo, Carlos; De Argila, Diego; García‐García, Carmen; Fraga, Javier; Marín, Alicia; Ballesteros, Ana Isabel; Daudén, Esteban
• Is Part Of: International journal of dermatology. Volume 55:Number 3(2016:Mar.)
• Page Start: e156
• Page End: e160
• Publication Date: 2015-11-13
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/ijd.13121
• Languages: English
• ISSNs: 0011-9059

Abstract

Abstract: Background: Eccrine porocarcinoma (EPC) is an uncommon malignant neoplasm that originates in the intraepidermal portion of the eccrine sweat duct. Although porocarcinoma is a slow‐growing tumor, up to 20% of cases can metastasize to regional lymph nodes, thus increasing mortality. Methods: We describe the clinical and histopathological features and clinical course of three cases of extensive metastatic EPC diagnosed in our department over the last 10 years. Results: All three patients were women aged 89–96 years. They had numerous skin tumors on the left leg that were histologically and immunohistochemically diagnosed as metastatic EPC. Only one patient had a history of primary porocarcinoma, which had been excised 6 years earlier. The remaining two patients had a previous lesion diagnosed as squamous cell carcinoma. We treated the patients with palliative radiotherapy and/or chemotherapy. Only one patient is currently alive. Conclusions: The cases of cutaneous and regional metastatic EPC we present occurred in elderly women with major involvement of the left leg. The third case is noteworthy, as the patient presented a long latency period before metastases appeared. Difficulties in the clinical diagnosis – and occasionally histological diagnosis – of primary EPC could delay more aggressive treatment, although optimal treatment does not always guarantee a good prognosis.