Protective effect of taurine against potassium bromate‐induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood. Issue 3 (12th September 2014)

• Record Type: Journal Article
• Authors: Ahmad, Mir Kaisar; Mahmood, Riaz
• Is Part Of: Environmental toxicology. Volume 31:Issue 3(2016)
• Page Start: 304
• Page End: 313
• Publication Date: 2014-09-12
• Subjects: blood -- lipid peroxidation -- methemoglobin -- oxidative stress -- potassium bromate -- taurine; Water quality bioassay -- Periodicals; Water -- Pollution -- Toxicology -- Periodicals; Microbiological assay -- Periodicals; Toxicity testing -- Periodicals; Environmental toxicology -- Periodicals; Environmental Pollution -- Periodicals; Environmental Pollutants -- Periodicals; Environmental Monitoring -- Periodicals; Écotoxicologie -- Périodiques; Pollution -- Périodiques; 615.902
• DOI: 10.1002/tox.22045
• Languages: English
• ISSNs: 1520-4081

Abstract

ABSTRACT: Potassium bromate (KBrO3 ) is widely used as a food‐additive and is a major water disinfection by‐product. KBrO3 causes severe toxicity in humans and experimental animals. Bromate is considered a probable human carcinogen and a complete carcinogen in animals. We have investigated the potential role of taurine in protecting against KBrO3 ‐induced oxidative stress in rat blood. Animals were given taurine for 5 days prior to KBrO3 and then sacrificed. Blood was collected and used to prepare hemolysates and plasma, which were then used for the analysis of several biochemical parameters. Administration of single oral dose of KBrO3 alone induced hepato‐ and nephro‐toxicity as evident by elevated marker levels in plasma. Lipid peroxidation and protein oxidation were increased both in plasma and erythrocytes, suggesting the induction of oxidative stress. KBrO3 increased methemoglobin, nitric oxide, and hydrogen peroxide levels. It also altered the activities of the major antioxidant enzymes and lowered the antioxidant power of blood. Administration of taurine, prior to treatment with KBrO3, resulted in significant attenuation in all these parameters but the administration of taurine alone had no effect. These results show that taurine is effective in mitigating the oxidative insult induced in rat blood by KBrO3 . © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 304–313, 2016.