BEt3‐Initiated Thiol–Ene Click Reactions as a Versatile Tool To Modify Sensitive Substrates1. Issue 36 (13th November 2015)

• Record Type: Journal Article
• Authors: Gorges, Jan; Kazmaier, Uli
• Is Part Of: European journal of organic chemistry. Issue 36(2015)
• Page Start: 8011
• Page End: 8017
• Publication Date: 2015-11-13
• Subjects: Click chemistry -- Radical reactions -- Thiol–ene reaction -- Thiols -- ­Alkenes -- Boranes; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201500915
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: BEt3 ‐initiated thiol–ene click reactions are an interesting alternative to the generally used thermal or photochemical thiol additions. The reactions proceed under very mild conditions, and require only 10 mol‐% of BEt3, and an almost stoichiometric amount of thiol. In this regard, this method is an attractive alternative to the other protocols, which often use the thiol component in a large excess. Abstract : BEt3 ‐initiated thiol–ene click reactions proceed under very mild conditions, and require only 10 mol‐% of BEt3 and an almost stoichiometric amount of thiol. The mild reaction conditions allow the modification of substrates containing functionalities that are senstitive to H‐abstraction.