Photocytotoxicity and G‐quadruplex DNA interaction of water‐soluble gallium(III) tris(N‐methyl‐4‐pyridyl)corrole complex. (15th December 2015)

• Record Type: Journal Article
• Authors: Zhang, Zhao; Wen, Jin‐Yan; Lv, Biao‐Biao; Li, Xu; Ying, Xiao; Wang, Ya‐Jun; Zhang, Hai‐Tao; Wang, Hui; Liu, Hai‐Yang; Chang, C.‐K.
• Is Part Of: Applied organometallic chemistry. Volume 30:Number 3(2016:Mar.)
• Page Start: 132
• Page End: 139
• Publication Date: 2015-12-15
• Subjects: corrole -- gallium -- photocytotoxicity -- G4 DNA -- anticancer activity; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.3408
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : A water‐soluble cationic gallium corrole, 5, 10, 15‐tris( N ‐methyl‐4‐pyridyl)corrolatogallium(III) (3 ), was prepared and characterized. The photocytotoxicity of3 was investigated using Hep G2 cancer cell line. Upon treatment with corrole3 and irradiation, fragmentation of tumor cell nuclei was observed, which led to apoptosis. Flow cytometric analysis clearly showed the efficient induction of apoptotic cell death, and corrole3 exhibited high photocytotoxicity towards Hep G2 cancer cells (IC50 = 60 nM). Furthermore, the binding behavior of corrole3 with c‐MYC G‐quadruplex DNA, a potent target for antitumor drugs, was investigated using spectroscopic methods and molecular docking simulation. Copyright © 2015 John Wiley & Sons, Ltd. Abstract : Water‐soluble cationic gallium–corrole complex3 exhibited high photocytotoxicity towards Hep G2 cancer cells. It is also a c‐MYC G‐quadruplex DNA stabilizer.