Putative tumor suppression function of SIRT6 in endometrial cancer. Issue 17 (13th July 2015)

• Record Type: Journal Article
• Authors: Fukuda, Tomohiko; Wada-Hiraike, Osamu; Oda, Katsutoshi; Tanikawa, Michihiro; Makii, Chinami; Inaba, Kanako; Miyasaka, Aki; Miyamoto, Yuichiro; Yano, Tetsu; Maeda, Daichi; Sasaki, Takeshi; Kawana, Kei; Fukayama, Masashi; Osuga, Yutaka; Fujii, Tomoyuki
• Is Part Of: FEBS letters. Volume 589:Issue 17(2015)
• Page Start: 2274
• Page End: 2281
• Publication Date: 2015-07-13
• Subjects: AMPK -- AMP-activated protein kinase -- DM -- diabetes mellitus -- EIC -- endometrial epithelial immortalized cells -- ERK -- extracellular signal-regulated kinase -- IGF1R -- insulin-like growth factor 1 receptor -- Endometrial cancer -- SIRT6 -- Survivin -- Apoptosis -- YM155; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2015.06.043
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : SIRT6, a member of the sirtuin family, has been identified as a candidate tumor suppressor. To pursue the role of SIRT6 in endometrial cancer, we investigated the anti‐tumorigenic function of SIRT6. The expression of SIRT6 negatively affected the proliferation of AN3CA and KLE endometrial cancer cells. Increased expression of SIRT6 resulted in the induction of apoptosis by repressing the expression of the anti‐apoptotic protein survivin. Consistent with this result, a survivin inhibitor YM155 efficiently inhibited cellular proliferation and induced apoptosis. These results revealed that SIRT6 might function as a tumor suppressor of endometrial cancer cells. Abstract : The expression of SIRT6 negatively affects the proliferation of endometrial cancer cells. SIRT6 induces apoptosis, and its induction is attributed to the repression of survivin. The SIRT6 downstream gene survivin could be a novel target for endometrial cancer treatment.