Synthesis, Characterization and Biological Evaluation of Two Silver(I) trans‐Cinnamate Complexes as Urease Inhibitors1. Issue 2 (22nd October 2013)

• Record Type: Journal Article
• Authors: Li, Xia; Wang, Yan; Li, Yuguang; Gou, Yi; Wang, Qiang
• Is Part Of: Zeitschrift für anorganische und allgemeine Chemie. Volume 640:Issue 2(2014)
• Page Start: 423
• Page End: 428
• Publication Date: 2013-10-22
• Subjects: Silver -- Solid‐state structures -- Substituent effects -- trans‐Cinnamate ligands -- Urease inhibitors; Chemistry, Inorganic -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1002/zaac.201300270
• Languages: English
• ISSNs: 0044-2313

Abstract

Abstract: Two new silver(I) trans ‐cinnamates, namely [Ag(2‐cca)(H2 O)]2 (1 ) and [Ag(4‐cca)] n (2 ) (2‐ccaH = 2‐chlorocinnamic acid and 4‐ccaH = 4‐chlorocinnamic acid), were synthesized and structurally characterized. Single crystal X‐ray studies reveal that each silver(I) atom in1 is two‐coordinate by a 2‐chlorocinnamate ligand and one water molecule to afford a discrete centrosymmetric dimer with the ligand‐unsupported Ag···Ag interactions (3.218(4) Å), while a pair of symmetry‐related silver(I) atoms in2 are clamped by two μ2 ‐η 1 :η 1 4‐chlorocinnamate ligands to yield a binuclear silver(I) moiety incorporating a ligand‐supported Ag···Ag interaction (2.819(5) Å). Both complexes1 and2 show potent urease inhibitory activities with the respective IC50 values of 0.66 and 1.10 μM. Abstract :