N‐α‐acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28β. Issue 11 (26th April 2013)

• Record Type: Journal Article
• Authors: Min, Li; Xu, Huiyu; Wang, Juan; Qu, Like; Jiang, Beihai; Zeng, Yan; Meng, Lin; Jin, Hongwei; Shou, Chengchao
• Is Part Of: FEBS letters. Volume 587:Issue 11(2013)
• Page Start: 1630
• Page End: 1637
• Publication Date: 2013-04-26
• Subjects: Naa10p -- N-α-acetyltransferase 10 protein -- PA28β -- proteasome activator 28β -- NatA -- N-acetyltransferase A -- shRNA -- short hairpin RNA -- Naa10p -- PA28β -- Proteasome activity; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.04.016
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Naa10p physically interacts with PA28 alpha and PA28 beta by anti bait coimmunoprecipitation (View Interaction: 1, 2) Abstract : Naa10p directly interacts with proteasome activator 28β (PA28β). Naa10p interacts with PA28α in a PA28β‐dependent manner. Naa10p inhibits PA28‐dependent chymotrypsin‐like proteasome activity. Naa10p regulates 28S proteasome activity independent of acetylation.