Deciphering post‐translational modification codes. Issue 8 (10th February 2013)

• Record Type: Journal Article
• Authors: Lothrop, Adam P.; Torres, Matthew P.; Fuchs, Stephen M.
• Is Part Of: FEBS letters. Volume 587:Issue 8(2013)
• Page Start: 1247
• Page End: 1257
• Publication Date: 2013-02-10
• Subjects: Post-translational modification -- Histone -- Phosphorylation -- Epigenetic -- Signaling -- Methylation; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.01.047
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Post‐translational modifications (PTMs) occur on nearly all proteins. Many domains within proteins are modified on multiple amino acid sidechains by diverse enzymes to create a myriad of possible protein species. How these combinations of PTMs lead to distinct biological outcomes is only beginning to be understood. This manuscript highlights several examples of combinatorial PTMs in proteins, and describes recent technological developments, which are driving our ability to understand how PTM patterns may "code" for biological outcomes.