ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling. Issue 6 (14th February 2013)

• Record Type: Journal Article
• Authors: Chang, Yan; Wang, Shao-Xin; Wang, Yu-Bo; Zhou, Jie; Li, Wei-Hua; Wang, Na; Fang, Di-Feng; Li, Hui-Yan; Li, Ai-Ling; Zhang, Xue-Min; Zhang, Wei-Na
• Is Part Of: FEBS letters. Volume 587:Issue 6(2013)
• Page Start: 607
• Page End: 613
• Publication Date: 2013-02-14
• Subjects: ECHS1 -- enoyl-CoA hydratase short chain 1 -- STAT3 -- signal transducer and activator of transcription 3 -- APRE -- acute phase response elements -- Enoyl-CoA hydratase short chain 1 -- Signal transducer and activator of transcription 3 -- Protein interaction -- Phosphorylation regulation; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.02.005
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : STAT3 physically interacts with ECHS1 by anti bait co immunoprecipitation (View interaction) Abstract : ► ECHS1 interacts with STAT3 in vitro and in vivo. ► ECHS1 inhibits the transcriptional activity of STAT3 induced by IL‐6 and EGF. ► ECHS1 decreases STAT3 tyrosine phosphorylation. ► ECHS1 negatively regulates expression of STAT3 target genes. ► We identify a novel STAT3 binding protein and reveal a new biological function of ECHS1 as regulator of STAT3 signaling.