DksA2, a zinc‐independent structural analog of the transcription factor DksA. Issue 6 (14th February 2013)

• Record Type: Journal Article
• Authors: Furman, Ran; Biswas, Tapan; Danhart, Eric M.; Foster, Mark P.; Tsodikov, Oleg V.; Artsimovitch, Irina
• Is Part Of: FEBS letters. Volume 587:Issue 6(2013)
• Page Start: 614
• Page End: 619
• Publication Date: 2013-02-14
• Subjects: DksA -- DksA2 -- RNA polymerase -- Zinc -- Cysteine; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.01.073
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : DksA2 and DksA2 bind by X‐ray crystallography (View interaction) Abstract : ► Structure of the zinc‐free DksA2 is similar to that of its zinc‐finger paralog DksA. ► DksA2 binds in the RNA polymerase secondary channel. ► A disulfide bond formed by two DksA2 cysteines plays a minor role in DksA2 activity. ► Substitutions of the two cysteine residues destabilize DksA2 structure.