Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development. Issue 4 (8th January 2013)

• Record Type: Journal Article
• Authors: Usui, Ayumi; Iwagawa, Toshiro; Mochizuki, Yujin; Iida, Atsumi; Wegner, Michael; Murakami, Akira; Watanabe, Sumiko
• Is Part Of: FEBS letters. Volume 587:Issue 4(2013)
• Page Start: 358
• Page End: 363
• Publication Date: 2013-01-08
• Subjects: Sox C family transcription factor -- Retina -- Development -- Transcriptional regulation -- Notch -- Histone modification; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2012.12.017
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Sox11 and Sox4 play critical roles in retinal development, during which they display specific and unique expression patterns. The expression of Sox11 and Sox4 is temporally sequential, albeit spatially overlapping in some retinal subtypes. Gain‐of‐function and loss‐of‐function analyses suggested that Notch signaling suppresses Sox4 expression in the early developing retina but not during the later period of development. The levels of histone H3‐acetylation and H3‐lysine 4 tri‐methylation at the Sox11 locus declined during development, as did the levels of Sox11. A similar but less marked change was seen for Sox4 . For both genes, histone H3‐lysine 27 methylation was low during development and increased markedly in the adult. Abstract : ► Expression of Sox11 and Sox4 changes during retinal development. ► Notch suppresses expression of Sox4 in retina in the early developmental stage. ► A role of histone modification in regulation of Sox11/4 is proposed.