Tumor suppressor protein VHL inhibits Hedgehog–Gli activation through suppression of Gli1 nuclear localization. Issue 7 (8th February 2013)

• Record Type: Journal Article
• Authors: Cho, Hyun Kook; Kim, So Young; Kim, Kook Hwan; Kim, Hyeong Hoe; Cheong, JaeHun
• Is Part Of: FEBS letters. Volume 587:Issue 7(2013)
• Page Start: 826
• Page End: 832
• Publication Date: 2013-02-08
• Subjects: VHL -- Gli -- Hedgehog signaling -- Tumor suppression; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.01.050
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : VHL physically interacts with GLI1 by pull down (View interaction) Abstract : ► Tumor suppressor protein VHL decreases the expression of Hedgehog–Gli1 gene. ► VHL represses Gli1‐mediated Hedgehog target gene expression. ► VHL interacts directly with Gli1 protein. ► VHL co‐localizes with Gli1 in the cytoplasm and disturbs Gli1 nuclear localization. ► These results suggest that VHL may act as a tumor suppressor in some Hedgehog‐related cancers.