Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin‐dependent kinase 5 activity. Issue 2 (20th January 2016)

• Record Type: Journal Article
• Authors: Liu, Xiaolong; BoseDasgupta, Somdeb; Jayachandran, Rajesh; Studer, Vera; Rühl, Sebastian; Stiess, Michael; Pieters, Jean
• Is Part Of: FEBS letters. Volume 590:Issue 2(2016)
• Page Start: 279
• Page End: 287
• Publication Date: 2016-01-20
• Subjects: cAMP/PKA signalling -- CDK5 -- Coronin 1 -- G protein alpha S -- Phosphorylation; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12046
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Coronins constitute a family of conserved proteins expressed in all eukaryotes that have been implicated in the regulation of a wide variety of cellular activities. Recent work showed an essential role for coronin 1 in the modulation of the cAMP/PKA pathway in neurons through the interaction of coronin 1 with the G protein subtype Gαs in a stimulus‐dependent manner, but the molecular mechanism regulating coronin 1‐Gαs interaction remains unclear. We here show that phosphorylation of coronin 1 on Thr 418/424 by cyclin‐dependent kinase (CDK) 5 activity was responsible for coronin 1‐Gαs association and the modulation of cAMP production. Together these results show an essential role for CDK5 activity in promoting the coronin 1‐dependent cAMP/PKA pathway. Abstract :