MiR‐889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP. Issue 10 (1st April 2015)

• Record Type: Journal Article
• Authors: Xu, Yanting; He, Jiangtu; Wang, Yue; Zhu, Xinyi; Pan, Qiuhui; Xie, Qiuling; Sun, Fenyong
• Is Part Of: FEBS letters. Volume 589:Issue 10(2015)
• Page Start: 1127
• Page End: 1135
• Publication Date: 2015-04-01
• Subjects: miR-889 -- DAB2IP -- Cell proliferation -- Esophageal squamous cell carcinoma; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2015.03.027
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : MicroRNAs have been reported to play critical roles in various cancers, but there has been no study on the role of miR‐889 in cancers. Here, we report that over‐expression of miR‐889 leads to rapid proliferation of EC109 and EC9706 cells in vitro and in vivo by inducing cells into S‐phase. Using bioinformatics methods, DAB2IP was further confirmed to be a direct target of miR‐889. In addition, the expression of DAB2IP, which was negatively correlated with that of miR‐889, was significantly associated with clinicopathological features of ESCC patients. In conclusion, miR‐889 is an important regulator in ESCC and both miR‐889 and DAB2IP may serve as promising biomarkers and therapeutic targets in patients with ESCC. Abstract : miR‐889 enhances esophageal squamous cell carcinoma cell proliferation. DAB2IP is a target of miR‐889. miR‐889 and DAB2IP correlate with clinicopathological features of ESCC patients.