Chicken IL‐6 is a heat‐shock gene. Issue 21 (18th September 2013)

• Record Type: Journal Article
• Authors: Prakasam, Ramachandran; Fujimoto, Mitsuaki; Takii, Ryosuke; Hayashida, Naoki; Takaki, Eiichi; Tan, Ke; Wu, Fangxu; Inouye, Sachiye; Nakai, Akira
• Is Part Of: FEBS letters. Volume 587:Issue 21(2013)
• Page Start: 3541
• Page End: 3547
• Publication Date: 2013-09-18
• Subjects: Fever -- Heat shock -- HSF -- IL-6 -- Inflammation; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.09.012
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : The febrile response is elicited by pyrogenic cytokines including IL‐6 in response to microorganism infections and diseases in vertebrates. Mammalian HSF1, which senses elevations in temperature, negatively regulates the response by suppressing pyrogenic cytokine expression. We here showed that HSF3, an avian ortholog of mammalian HSF1, directly binds to and activates IL‐6 during heat shock in chicken cells. Other components of the febrile response mechanism, such as IL‐1β and ATF3, were also differently regulated in mammalian and chicken cells. These results suggest that the febrile response is exacerbated by a feed‐forward circuit composed of the HSF3‐IL‐6 pathway in birds. Abstract : IL‐6 expression is induced during heat shock in chicken cells. Chicken HSF3 directly binds to and activates the IL‐6 gene during heat shock. Regulation of IL‐6 and other febrile response components evolutionally diverged in mammals and birds.