Inhibition effect of enteropeptidase on RANKL–RANK signalling by cleavage of RANK. Issue 18 (13th August 2013)

• Record Type: Journal Article
• Authors: Zhao, Yunfeng; Jin, Mengmeng; Ma, Juan; Zhang, Shiqian; Li, Wei; Chen, Yuan; Zhou, Yingsheng; Tao, Hong; Liu, Yu; Wang, Lei; Han, Huamin; Niu, Ge; Tao, Hua; Liu, Changzhen; Gao, Bin
• Is Part Of: FEBS letters. Volume 587:Issue 18(2013)
• Page Start: 2958
• Page End: 2964
• Publication Date: 2013-08-13
• Subjects: EP -- enteropeptidase -- BMM -- bone marrow-derived macrophage -- RANKL -- receptor of activator of NF-κB ligand -- RANK -- receptor of activator of NF-κB -- TNFRSF18 -- tumour necrosis factor receptor superfamily 18 -- M-CSF -- macrophage-colony stimulating factor -- TRAP -- tartrate-resistant acid phosphatase -- Enteropeptidase/EP -- RANKL–RANK signalling pathway -- Osteoclastogenesis; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.08.005
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : EPcleaves mRANK bycleavage assay (View interaction) Abstract : There is a cleavage site on RANK for enzyme enteropeptidase. Enteropeptidase can block osteoclastogenesis by the cleavage of RANK. RANK can be used as a target to block RANKL–RANK signalling.