Osteoclastogenic activity of translationally‐controlled tumor protein (TCTP) with reciprocal repression of p21. Issue 21 (27th September 2014) - Choi, Sik-Won
Abstract : Translationally‐controlled tumor protein (TCTP) plays a role in a number of cellular processes, but there is limited information about its function in cell differentiation. Previous observations of a twofold induction of TCTP mRNA during osteoclast differentiation prompted us to investigate its involvement in osteoclast differentiation. The osteoclastogenicity of TCTP gradually expressed during osteoclast differentiation was confirmed in mouse and human cells using loss‐of‐function studies and TCTP heterogeneous mice and transgenic mice. Higher expression ratios of TCTP to p21 could represent TCTP‐mediated phenotypic induction of osteoclast differentiation accompanied by p21 down‐regulation, attenuating the proliferation of osteoclast precursor cells. Abstract : TCTP is induced during osteoclast differentiation. TCTP knockdown inhibits osteoclast differentiation. TCTP knockdown inhibits osteoclast precursor cell proliferation with p21 induction. TCTP +/− mice had increased bone mass with decreased osteoclasts. TCTP transgenic mice had decreased bone mass and increased osteoclasts.