Mistranslation of the genetic code. Issue 23 (16th September 2014)

• Record Type: Journal Article
• Authors: Moghal, Adil; Mohler, Kyle; Ibba, Michael
• Is Part Of: FEBS letters. Volume 588:Issue 23(2014)
• Page Start: 4305
• Page End: 4310
• Publication Date: 2014-09-16
• Subjects: Amino acid -- Mistranslation -- Protein synthesis -- Quality control -- Translation -- tRNA; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2014.08.035
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : During mRNA decoding at the ribosome, deviations from stringent codon identity, or "mistranslation, " are generally deleterious and infrequent. Observations of organisms that decode some codons ambiguously, and the discovery of a compensatory increase in mistranslation frequency to combat environmental stress have changed the way we view "errors" in decoding. Modern tools for the study of the frequency and phenotypic effects of mistranslation can provide quantitative and sensitive measurements of decoding errors that were previously inaccessible. Mistranslation with non‐protein amino acids, in particular, is an enticing prospect for new drug therapies and the study of molecular evolution.