Inhibitory role of polyunsaturated fatty acids on lysophosphatidic acid‐induced cancer cell migration and adhesion. Issue 17 (6th June 2014)

• Record Type: Journal Article
• Authors: Kim, Eun Kyoung; Ha, Jung Min; Kim, Young Whan; Jin, Seo Yeon; Ha, Hong Koo; Bae, Sun Sik
• Is Part Of: FEBS letters. Volume 588:Issue 17(2014)
• Page Start: 2971
• Page End: 2977
• Publication Date: 2014-06-06
• Subjects: AA -- arachidonic acid -- CaM -- calmodulin -- CaMKII -- CaM-dependent kinase II -- DHA -- docosahexaenoic acid -- ECM -- extracellular matrix -- ELA -- ethyl linoleate -- ELN -- ethyl linolenate -- EPA -- eicosapentaenoic acid -- FAs -- focal adhesions -- LA -- linoleic acid -- LNA -- α-linolenic acid -- LPA -- lysophosphatidic acid -- PUFAs -- polyunsaturated fatty acids -- α-Linolenic acid -- Lysophosphatidic acid -- Migration -- Adhesion -- Vinculin -- Calcium mobilization; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2014.05.052
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Polyunsaturated fatty acids (PUFAs) have important pharmacological effects on mammalian cells. Here, we show that carboxyl group‐containing PUFAs inhibit lysophosphatidic acid (LPA)‐induced focal adhesion formation, thereby inhibiting migration and adhesion. Carboxyl group‐containing PUFAs inhibit LPA‐induced calcium mobilization, whereas ethyl ester‐group containing PUFAs have no effect. In addition, carboxyl group‐containing PUFAs functionally inhibit LPA‐dependent RhoA activation. Given these results, we suggest that PUFAs may inhibit LPA‐induced calcium/RhoA signaling pathways leading to focal adhesion formation. Carboxyl group‐containing PUFAs may have a functional role in this regulatory mechanism. Abstract : Polyunsaturated fatty acids have a beneficial effect on cancer patients. Inhibitory role of various polyunsaturated fatty acids was determined. Carboxyl group has a functional role in the inhibition of cancer cell migration. Calcium mobilization and RhoA activation is abrogated by PUFAs. PUFAs inhibit cancer cell migration by blocking focal adhesion formation.