Peptides derived from HIV‐1 gp120 co‐receptor binding domain form amyloid fibrils and enhance HIV‐1 infection. Issue 9 (18th March 2014)

• Record Type: Journal Article
• Authors: Tan, Suiyi; Li, Lin; Lu, Lu; Pan, Chungen; Lu, Hong; Oksov, Yelena; Tang, Xiaojuan; Jiang, Shibo; Liu, Shuwen
• Is Part Of: FEBS letters. Volume 588:Issue 9(2014)
• Page Start: 1515
• Page End: 1522
• Publication Date: 2014-03-18
• Subjects: HIV-1 gp120 -- Amyloid fibrils -- Enhancement of HIV-1 infection -- EGCG -- Antiretroviral drugs; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2014.03.016
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : SEVI and SEVI bind by transmission electron microscopy (View interaction) Abstract : EPs derived from HIV‐1 gp120 significantly enhance HIV‐1 infection. EPs target the virus entry process to boost HIV‐1 infection. EPs suppress the anti‐HIV‐1 activity of ARVs. EGCG antagonizes the EP‐mediated enhancement of HIV‐1 infection. EPs might be effective agents to promote retroviral gene transfer.