Hsa‐miR‐125b suppresses bladder cancer development by down‐regulating oncogene SIRT7 and oncogenic long non‐coding RNA MALAT1. Issue 23 (26th October 2013)

• Record Type: Journal Article
• Authors: Han, Yonghua; Liu, Yuchen; Zhang, Hu; Wang, Tiantian; Diao, Ruiying; Jiang, Zhimao; Gui, Yaoting; Cai, Zhiming
• Is Part Of: FEBS letters. Volume 587:Issue 23(2013)
• Page Start: 3875
• Page End: 3882
• Publication Date: 2013-10-26
• Subjects: Bladder cancer -- MicroRNA -- Hsa-miR-125b -- SIRT7 -- Long non-coding RNA -- MALAT1; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.10.023
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : MicroRNAs mainly inhibit coding genes and long non‐coding RNA expression. Here, we report that hsa‐miR‐125b and oncogene SIRT7/oncogenic long non‐coding RNA MALAT1 were inversely expressed in bladder cancer. Hsa‐miR‐125b mimic down‐regulated, whereas hsa‐miR‐125b inhibitor up‐regulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsa‐miR‐125b and SIRT7/MALAT1. Up‐regulation of hsa‐miR‐125b or down‐regulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of up‐regulation of hsa‐miR‐125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa‐miR‐125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1. Abstract : Hsa‐miR‐125b and SIRT7/MALAT1 are inversely expressed in bladder cancer. Hsa‐miR‐125b inhibits bladder cancer cell growth and motility, and increases apoptosis. Hsa‐miR‐125b downregulates oncogene SIRT7 in bladder cancer. Hsa‐miR‐125b downregulates oncogenic long non‐coding RNA MALAT1 in bladder cancer. Hsa‐miR‐125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1.