Determination of Human Chorionic Gonadotropin in Postmortem Samples in Ectopic Pregnancies. Issue 1 (7th August 2015)

• Record Type: Journal Article
• Authors: Palmiere, Cristian; Lesta, Maria del Mar; Fanton, Laurent; Ventura, Francesco; Bonsignore, Alessandro; Reggiani Bonetti, Luca
• Is Part Of: Journal of forensic sciences. Volume 61:Issue 1(2016)
• Page Start: 234
• Page End: 237
• Publication Date: 2015-08-07
• Subjects: forensic science -- human chorionic gonadotropin -- pericardial fluid -- cerebrospinal fluid -- ectopic pregnancy -- postmortem biochemistry -- autopsy; Medical jurisprudence -- Periodicals; Forensic sciences -- Periodicals; Forensic Medicine -- Periodicals; Gerechtelijke geneeskunde; Gerechtelijke chemie; Gerechtelijke psychiatrie; 363.2505
• DOI: 10.1111/1556-4029.12885
• Languages: English
• ISSNs: 0022-1198

Abstract

Abstract: Increased human chorionic gonadotropin levels (HCG) can be detected in femoral blood, bile, and vitreous humor collected during autopsy of pregnant women using a standard kit designed for living patients. In the study herein, the concentrations of HCG were measured in postmortem serum, vitreous, bile, cerebrospinal, and pericardial fluids in 4 cases of fatal ectopic pregnancy and 40 controls using a quantitative electrochemiluminescence immunoassay designed for living patients. No false‐negative cases were identified in any of the analyzed samples in any of the ectopic pregnancy cases. No correlations were found between total HCG levels in postmortem serum and the other tested specimens. The results of this study would suggest that higher HCG in bile, vitreous, pericardial, and cerebrospinal fluids may confirm the existence of ectopic pregnancy and therefore identify other situations in which this hormone is increased, although gestational age cannot be reliably estimated using these values.