Haematological and immunological adaptations of non-pregnant, non-lactating dairy cows to a high-energetic diet containing mycotoxins. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Dänicke, Sven; Meyer, Ulrich; Winkler, Janine; Ulrich, Sebastian; Frahm, Jana; Kersten, Susanne; Valenta, Hana; Rehage, Jürgen; Häussler, Susanne; Sauerwein, Helga; Locher, Lena
• Is Part Of: Archives of animal nutrition. Volume 70:Issue 1(2016)
• Page Start: 1
• Page End: 16
• Publication Date: 2016-01-02
• Subjects: Dairy cows -- deoxynivalenol -- energy consumption -- functional responses -- haematology -- leucocytes -- mycotoxins -- zearalenone; Animal nutrition -- Periodicals; Animal Nutrition -- Periodicals; Animal Feed -- Periodicals; 636.085205
• DOI: 10.1080/1745039X.2015.1117561
• Languages: English
• ISSNs: 1745-039X

Abstract

Abstract: Diet change and fatness are supposed to challenge the immune system of the cow. Therefore, immunological and haematological consequences of adaptation to and continued feeding of a high-energy diet were studied in eight non-pregnant, non-lactating Holstein cows over 16 weeks. Blood haptoglobin concentration remained unaltered, suggesting that an acute phase reaction was not induced. Stimulation ability of peripheral blood mononuclear cells and stimulated oxidative burst capacity of granulocytes increased significantly in the course of the experiment after an initial drop. While total leucocyte counts increased, the proportion of granulocytes increased and that of lymphocytes decreased at the same time as the ratio of CD4 + /CD8 + lymphocytes did. Capability of rumen microbes to detoxify the immune-modulating mycotoxin deoxynivalenol (DON) was not compromised as indicated by the exclusive presence of de-DON as the detoxified DON metabolite in blood. In conclusion, both diet change and prolonged positive energy balance influenced the bovine immune system.