A new diketopiperazine derivative from a deep sea-derived Streptomyces sp. SCSIO 04496. Issue 2 (17th January 2016)

• Record Type: Journal Article
• Authors: Luo, Minghe; Tang, Guiling; Ju, Jianhua; Lu, Laichun; Huang, Hongbo
• Is Part Of: Natural product research. Volume 30:Issue 2(2016)
• Page Start: 138
• Page End: 143
• Publication Date: 2016-01-17
• Subjects: diketopiperazine -- cyclodipeptide -- Streptomyces sp.; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1045509
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract : A new diketopiperazine (DKP) derivative, (6 R, 3 Z )-3-benzylidene-6-isobutyl-1-methyl piperazine-2, 5-dione (1 ), as well as five known DKPs2 –6 was isolated from a deep sea-derived Streptomyces sp. SCSIO 04496. The structure of1 was elucidated using a combination of 1D and 2D NMR, HR-ESI-MS and chiral-phase HPLC techniques. Compounds1 –6 did not show cytotoxic activity at a concentration of 100 μM in bioactivity assay. Abstract :