Two new sesquiterpene lactones from the fruits of Illicium jiadifengpi. Issue 3 (1st February 2016)

• Record Type: Journal Article
• Authors: Liu, Jifeng; Liu, Feiyan; Zhang, Nenling; Wang, Yafeng; Yang, Lijia; Bi, Yuefeng; Zhang, Yanbing; Liu, Mengqi
• Is Part Of: Natural product research. Volume 30:Issue 3(2016)
• Page Start: 322
• Page End: 326
• Publication Date: 2016-02-01
• Subjects: Illicium jiadifengpi -- sesquiterpene lactones -- anti-HBV activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1058793
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract : Two new seco -prezizaane-type sesquiterpenes, 3, 4-dehydroneomajucin (1 ) and 1, 2, 3, 4-tetradehydroneomajucin (2 ), were isolated from the fruits of Illicium jiadifengpi . The structure of these compounds was determined using 1D and 2D NMR and ESI-MS. The isolates were evaluated for their anti-hepatitis B virus activities on the Hep G2.2.15 cell line. The inhibitory rates of compounds1 and2 on the HBeAg and HBsAg expression were 30.08 ± 3.09% and 11.43 ± 1.92% at a concentrations of 68.00 μM and 7.88 ± 1.21% and 16.96 ± 4.24% at a concentration of 68.50 μM, respectively. Abstract :