A novel cyclic dipeptide from deep marine-derived fungus Aspergillus sp. SCSIOW2. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Zhou, Xiang; Fang, Pingyan; Tang, Jianqiang; Wu, Zhiqin; Li, Xiaofan; Li, Shuiming; Wang, Yong; Liu, Gang; He, Zhendan; Gou, Deming; Yao, Xinsheng; Wang, Liyan
• Is Part Of: Natural product research. Volume 30:Issue 1(2016)
• Page Start: 52
• Page End: 57
• Publication Date: 2016-01-02
• Subjects: marine fungi -- nitric oxide inhibitory activity -- cyclodipeptide -- Aspergillus sp; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1033623
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract : A novel cyclic dipeptide, 14-hydroxy-cyclopeptine (1 ), was purified from a deep sea derived fungal isolate identified as an Aspergillus sp. The structure was elucidated by detailed spectroscopic analyses using 1D and 2D NMR experiments and high resolution mass spectrometry. The absolute configuration of the amino acid was determined by Marfey's method. Two conformational isomers of1 were established by ROE analyses.1 inhibited nitric oxide production with IC50 values at 40.3 μg/mL in a lipopolysaccharide and recombinant mouse interferon-γ -activated macrophage-like cell line, RAW 264.7 and showed no cytotoxic effect in the tested dose range up to 100 μg/mL. Abstract :