The effect of topical ethanol extract of Cotinus coggygria Scop. on cutaneous wound healing in rats. Issue 4 (16th February 2016)

• Record Type: Journal Article
• Authors: Aksoy, Halil; Sancar, Mesut; Sen, Ali; Okuyan, Betul; Bitis, Leyla; Uras, Fikriye; Akakin, Dilek; Cevik, Ozge; Kultur, Sukran; İzzettin, Fikret Vehbi
• Is Part Of: Natural product research. Volume 30:Issue 4(2016)
• Page Start: 452
• Page End: 455
• Publication Date: 2016-02-16
• Subjects: wound healing -- hydroxyproline -- Cotinus coggygria Scop; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1019349
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract : The aim of this study is to determine the cutaneous wound healing effects of the ethanol extract of Cotinus coggygria leaves in rats by excision wound model to provide scientific evidence for the traditional use of C. coggygria Scop. The levels of malondialdehyde, catalase, superoxide dismutase, glutathione and hydroxyproline were investigated in wound tissues. Histopathological examination was also performed. The hydroxyproline content of the granulation tissue and the glutathione levels were both significantly higher in the treatment group than in the control group ( p < 0.05 for both); while the malondialdehyde levels were significantly lower in the treatment group ( p < 0.05). These results were supported with histological results. The ethanol extract of C. coggygria Scop could be considered as an effective agent in wound healing in accordance with its traditional use. Abstract :