Anti-inflammatory flavanol glycosides from Saraca asoca bark. Issue 4 (16th February 2016)

• Record Type: Journal Article
• Authors: Ahmad, Furkan; Misra, Laxminarain; Tewari, Rashi; Gupta, Preeti; Mishra, Pratikshita; Shukla, Rakesh
• Is Part Of: Natural product research. Volume 30:Issue 4(2016)
• Page Start: 489
• Page End: 492
• Publication Date: 2016-02-16
• Subjects: Saraca asoca (Roxb.) de Wild. syn. S. indica Linn -- flavan-3-O-glycosides -- anti TNF-α activity -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1023728
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract : Saraca asoca (Roxb.) de Wilde, a common tree of India, is popularly used in the Ayurvedic and modern herbal systems of medicine for genito-urinary problems of women. Considering the reported antimicrobial or anti-inflammatory effect of S. asoca bark against such infections, we studied the anti-inflammatory activity-guided isolation of active compounds from methanol extract. The methanol extract of bark has yielded 10 compounds out of which 3′-deoxyepicatechin-3- O -β-d -glucopyranoside (6 ) and 3′-deoxycatechin-3- O -α-l -rhamnopyranoside (8 ) have been found to be in vitro and in vivo active. 3′, 5-Dimethoxy epicatechin (3 ), 3′-deoxyepicatechin-3- O -β-d -glucopyranoside (6 ), 3′-deoxycatechin-3- O -α-l -rhamnopyranoside (8 ) and epigallocatechin (9 ) are being reported for the first time from S. asoca . Abstract :