Advanced glycation end-products inhibitors isolated from Schisandra grandiflora. Issue 4 (16th February 2016)

• Record Type: Journal Article
• Authors: Poornima, B.; Anand Kumar, D.; Siva, Bandi; Venkanna, A.; Vadaparthi, P.R. Rao; Kumar, K.; Tiwari, Ashok K.; Suresh Babu, K.
• Is Part Of: Natural product research. Volume 30:Issue 4(2016)
• Page Start: 493
• Page End: 496
• Publication Date: 2016-02-16
• Subjects: Schisandra grandiflora -- diabetes -- free radical scavenging activity -- advanced glycation end-products inhibitor; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1024117
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract : Free radicals scavenging and advanced glycation end-products (AGEs) inhibitory potentials in crude chloroform extract of Schisandra grandiflora were evaluated. Bioassay-guided isolation of the chloroform extract led to the identification of 24 compounds. Among the isolates, ( ± ) gomisin M1, arisantetralone C and D, macelignan, saurulignan B and SZ-MO displayed potent-free radical scavenging as well as AGEs inhibitory potentials. This is the first report identifying the presence of AGEs inhibitory activity and assigning AGEs inhibitory activity to these compounds. Therefore, our research finds new application of traditional medicinal plant S. grandiflora having capacity to reduce formation and accumulation of AGEs in diabetes. Abstract :