Diffusion model to describe osteogenesis within a porous titanium scaffold. Issue 2 (25th January 2016)

• Record Type: Journal Article
• Authors: Schmitt, M.; Allena, R.; Schouman, T.; Frasca, S.; Collombet, J.M.; Holy, X.; Rouch, P.
• Is Part Of: Computer methods in biomechanics and biomedical engineering. Volume 19:Issue 2(2016)
• Page Start: 171
• Page End: 179
• Publication Date: 2016-01-25
• Subjects: bone scaffold -- osteogenesis -- in vivo test -- finite element method -- mechanobiology; Biomechanics -- Data processing -- Periodicals; Biomedical engineering -- Periodicals; Biomechanics -- Periodicals; Biomedical Engineering -- methods -- Periodicals; Computing Methodologies -- Periodicals; 612.7
• DOI: 10.1080/10255842.2014.998207
• Languages: English
• ISSNs: 1025-5842

Abstract

Abstract : In this study, we develop a two-dimensional finite element model, which is derived from an animal experiment and allows simulating osteogenesis within a porous titanium scaffold implanted in ewe's hemi-mandible during 12 weeks. The cell activity is described through diffusion equations and regulated by the stress state of the structure. We compare our model to (i) histological observations and (ii) experimental data obtained from a mechanical test done on sacrificed animal. We show that our mechano-biological approach provides consistent numerical results and constitutes a useful tool to predict osteogenesis pattern.