Characterization of naproxen–polymer conjugates for drug-delivery. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Forte, Gianpiero; Chiarotto, Isabella; Giannicchi, Ilaria; Loreto, Maria Antonietta; Martinelli, Andrea; Micci, Roberta; Pepi, Federico; Rossi, Serena; Salvitti, Chiara; Stringaro, Annarita; Tortora, Luca; Vecchio Ciprioti, Stefano; Feroci, Marta
• Is Part Of: Journal of biomaterials science. Volume 27:Issue 1(2016)
• Page Start: 69
• Page End: 85
• Publication Date: 2016-01-02
• Subjects: Drug delivery -- PEGylation -- polypyrrole -- drug–polymer conjugates -- naproxen -- NSAID; Polymers -- Biocompatibility -- Periodicals; Biomedical materials -- Periodicals; 572.33
• DOI: 10.1080/09205063.2015.1108637
• Languages: English
• ISSNs: 0920-5063

Abstract

Abstract: The synthesis and the characterization of three new naproxen decorated polymers are described. A versatile and general approach is employed to link the drug to polymers, affording the derivatives with a very high degree of purity. The release of the drug from the conjugates proved to be exceptionally slow, even in acidic aqueous media, and the kinetic of the process seems to be triggered by their solubility in water. On the other hand, the interesting outcome of the first ex vivo drug release experiments on human blood samples makes this preliminary study valuable for future investigations on the use of these polymeric prodrugs in in vivo treatment of inflammatory states.